in research1 Researchers evaluating the efficacy and safety of microwave devices in patients with axillary hyperhidrosis and bromhidrosis found that 90% of patients experienced a reduction in symptoms of hyperhidrosis, and the majority reported odor. have been found to achieve a reduction in
This research Journal of Cosmetic Dermatologyevaluated the efficacy of microwave therapy, a non-invasive and relatively new treatment in the field of hyperhidrosis. Researchers Tan et al. noted that the energy and long-term efficacy of microwave devices have not yet been clinically validated due to the lack of research on this indication.
A total of 20 patients diagnosed with axillary hyperhidrosis and with a Hyperhidrosis Severity Scale (HDSS) score of at least grade 3 were enrolled in the study. All participants were adults between the ages of 18 and 50 who presented with symptoms of osmidorosis and axillary sweating but had not received any treatment for these symptoms within at least 6 months. In addition, all patients were required to have a positive bilateral axillary iodine starch test. All patients had underarm odor, but this was not considered an inclusion criterion.
Prospective patients were excluded only if they had a history of severe systemic illness and/or an allergy to swollen anesthetic fluid.
All participants underwent sweat and odor assessments before and after receiving microwave treatment. The investigators used hematoxylin and eosin staining and CAM5.2 histologic staining to assess histologic changes in the axillary sweat glands. They also assessed the severity of axillary odor using a visual analogue scale (VAS), and the odor -5 subscale and the Youngjin Park grading to assess effectiveness of treatment with respect to odor conspicuity and odor presence. was judged.
Treatment efficacy was also determined using HDSS grading, and changes in psychological status and quality of life were tracked using the Psychological Condition Symptom Checklist (SCL) and the Dermatology Life Quality Index (DLQI).
Before treatment, all patients were photographed and anesthetized using lidocaine, epinephrine, and sodium bicarbonate after lubricating the bilateral axillae. Swelling anesthetic was injected into both the lateral axillary wall and the unilateral axilla.
The MiraDry microwave device was then used in combination with a biochip treatment head to reduce negative pressure on the treatment area while avoiding thermal damage to the skin. Throughout the treatment process, participants were asked to identify burning, pain, and tingling sensations. When these sensations were identified, the device switched to cooling rather than heating.
After treatment, participants were provided ice packs and ibuprofen to reduce pain and side effects. Participants were then instructed to maintain a twice-daily underarm washing routine while avoiding excessive movement or rubbing of the treatment area.
Follow-up visits were completed 30 days and 3, 6, 9 and 12 months after treatment. At 12 months after treatment, all participants rated their odor and sweat symptoms using a subjective score based on their degree of satisfaction or satisfaction with the outcome of receiving treatment.
After treatment, the investigators noted a significant reduction in HDSS grade from baseline. In fact, his 90% of her HDSS grades of patients fell from grades 3 or 4 to below grades 1 and 2. Furthermore, according to VAS, 75% of patients had a 50% or less odor reduction.
Statistically significant improvements were also noted in the Young-Jin Park classification and Odor-5 scores at each consecutive follow-up visit.
Quality of life and psychological improvements were also notable and statistically significant. At baseline, 70% of patients experienced moderate to severe quality of life impact from hyperhidrosis. After treatment this he decreased to 25%. The pretreatment SCL score averaged 113.5. After treatment, the mean score decreased to 94.
Moreover, both the intensity of histopathology and the number of sweat glands were significantly reduced after treatment.
Adverse effects of microwave therapy were mild in nature, primarily heat-related tissue damage. Most of his side effects resolved within 5 weeks of starting treatment.
According to Tan et al., “The cost of miraDry treatment is higher than other treatments, but we believe that the long-lasting or permanent results are an advantage.” “The long-term effectiveness of this treatment can be inferred based on the fact that sweat glands are derived from fetal tissue and cannot be regenerated. We will continue to track the effectiveness of Up participants.”
- Tan Y, Huang W, Liu J, et al. Application of microwaves in axillary hyperhidrosis: Observation of therapeutic effect by pathological examination over one year. J Cosm Dermatol. It will be published online on August 7, 2023. Doi: 10.1111/jocd.15909