A new study by scholars from Royal Holloway and the University of Western Ontario shows that fetal cells left over from previous pregnancies with multiple partners in pregnant women can contribute to pregnancies such as pre-eclampsia and post-pregnancy autoimmune diseases. It suggests that it may increase the risk of health complications. pregnancy.
The article will be published in a journal Proceedings of the Royal Society B: Biological Sciences.
A mother retains fetal cells with each pregnancy throughout her life. These cells are genetically different from their mother’s own cells because they receive half of their genes from their mother and the other half from their father. The persistence of fetal cells in the mother’s body transforms them into what scientists call microchimeras.
The term microchimera is used by mothers to form by combining cells from different bodies of themselves and all of their children, just as mythical chimeras were formed by combining the bodies of lions, snakes and goats. It reflects that.
Maternal progeny cells, the fetal microchiome, are thought to be associated with autoimmune and reproductive health problems, but their role in causing these health complications is unknown.
The key may be the genetic diversity of progeny cells conferred by mate diversity and the availability of this information within the mother’s own body.
Interestingly, previous research found that pregnant women who had different partners in previous pregnancies were 10 times more likely to experience pre-eclampsia than those who had the same partner.
“This evolutionary study is particularly interesting because we don’t know why women conceived with different partners develop more health complications over time,” said Francisco Ubeda, professor of biology at Royal Holloway University. Ta.
“This is consistent with medical observations that mothers experiencing pre-eclampsia are more likely to have microchimeric cells, and mothers with multiple partners are more likely to experience pre-eclampsia. I’m here.
“In this role, we argue that genetically diverse microchiomes are likely to cause health problems and propose medical interventions to address these problems. It is to change the composition of the microchiome from more diverse to less diverse by removing” or equivalent cells. ”
For more information:
Francisco Úbeda et al., Microchimerism as an information source for future pregnancies, Proceedings of the Royal Society B: Biological Sciences (2023). DOI: 10.1098/rspb.2023.1142
Courtesy of Royal Holloway, University of London
Quote: Autoimmune, reproductive problems in women who have given birth to multiple partners may be caused by cells from previous pregnancies (25 Aug 2023) https://medicalxpress.com/news/2023-08 -autoimmune-reproduction-problems-, obtained on 25 August 2023 Female Multiple.html
This document is subject to copyright. No part may be reproduced without written permission, except in fair trade for personal study and research purposes. Content is provided for informational purposes only.